在健康志愿者中比较铝镁加和氢氧化铝对五肽胃泌素诱导的胃酸分泌的抗酸特性。

Comparison of the antacid properties of almagate and aluminium hydroxide against pentagastrin-induced gastric secretion in healthy volunteers.

作者信息

Balanzó J, Guarner C, Vilardell F

出版信息

Arzneimittelforschung. 1984;34(10A):1375-7.

Abstract

The potency of a new antacid, almagate (hydrated aluminium-magnesium hydroxycarbonate, Al2Mg6 (OH)14(CO3)2 X 4 H2O, Almax) has been compared with that of aluminium hydroxide in neutralizing pentagastrin-induced hyperacidity in healthy human volunteers. Almagate (1 g) produced a significantly (p less than 0.01) greater reduction (87.5%) in the titratable acid content of gastric aspirates than did an identical dose of aluminium hydroxide (45.1%). Similarly the pepsin proteolytic activity in the samples of gastric juice was reduced 58.9% by almagate and only 27.5% by aluminium hydroxide. Furthermore the neutralizing effect of almagate was more prolonged (90 min) than that of the standard antacid (30 min) and these first studies in man have therefore confirmed the findings of in vitro and in vivo preclinical experiments.

摘要

已将新型抗酸剂铝镁加（水合铝镁羟基碳酸盐，Al2Mg6(OH)14(CO3)2·4H2O，Almax）与氢氧化铝在中和健康人类志愿者中五肽胃泌素诱导的胃酸过多方面的效力进行了比较。铝镁加（1克）使胃抽吸物中可滴定酸含量的降低幅度（87.5%）显著（p<0.01）大于相同剂量的氢氧化铝（45.1%）。同样，铝镁加使胃液样本中的胃蛋白酶蛋白水解活性降低了58.9%，而氢氧化铝仅使其降低了27.5%。此外，铝镁加的中和作用比标准抗酸剂更持久（90分钟），而标准抗酸剂的中和作用为30分钟，因此这些在人体中的初步研究证实了体外和体内临床前实验的结果。