Fábregas J L, Beneyto J E
Arzneimittelforschung. 1984;34(10A):1354-7.
The stability under accelerated conditions of almagate (Al2Mg6(OH)14(CO3)2 X 4 H2O, Almax) a new crystalline synthetic hydrated aluminium-magnesium hydroxycarbonate antacid, and pharmaceutical formulations prepared from it, were compared with other pharmaceutical formulations prepared from aluminium hydroxide gel or co-gels of aluminium-magnesium hydroxide. The antacid properties of almagate, Almax tablets and suspension, did not change during eight months storage at 60 degrees C whereas preparations of aluminium hydroxide gel and aluminium-magnesium hydroxide co-gel suffered considerable losses in acid neutralization capacity. Neither the X-ray diffraction nor the IR absorption spectrum of almagate changed during storage for 8 months at 60 degrees C. Thus almagate and pharmaceutical formulations prepared from it are thermally stable and will maintain their antacid properties for long periods of time unlike products prepared from aluminium hydroxide gels or aluminium-magnesium hydroxide co-gels.
将新型结晶合成水合铝镁羟基碳酸盐抗酸剂铝碳酸镁（Al2Mg6(OH)14(CO3)2·4H2O，Almax）及其制备的药物制剂在加速条件下的稳定性，与由氢氧化铝凝胶或氢氧化铝镁共凝胶制备的其他药物制剂进行了比较。铝碳酸镁、Almax片剂和混悬液的抗酸性能在60℃储存八个月期间未发生变化，而氢氧化铝凝胶制剂和氢氧化铝镁共凝胶制剂的酸中和能力则有相当大的损失。铝碳酸镁在60℃储存8个月期间，其X射线衍射和红外吸收光谱均未改变。因此，铝碳酸镁及其制备的药物制剂具有热稳定性，与由氢氧化铝凝胶或氢氧化铝镁共凝胶制备的产品不同，它们能长时间保持其抗酸性能。
