Llupiá J, Beckett P R, Lumachi B, Roberts D J
Arzneimittelforschung. 1984;34(10A):1370-2.
The efficacies of almagate (hydrated aluminium-magnesium hydroxycarbonate, Al2Mg6(OH)14(CO3)2 X 4H2O, Almax) and aluminium hydroxide to neutralise histamine-induced gastric acid hypersecretion were compared in a closed-circuit perfused stomach preparation modified for pH-stat titration in the intact, anaesthetised rat. After intravenous injection of histamine (0.75 mg/kg), the amount of antacid automatically added to the closed system to maintain the stomach perfusion fluid at pH 4 was measured during 60 min. The results obtained show that the acid neutralising capacity of almagate in this hypersecretion model was some 8 times greater than that of aluminium hydroxide. Analysis of the titration curves obtained also demonstrates that the velocity of neutralisation to pH 4 at the start of the experiment was considerably more rapid with almagate. It is concluded that almagate will be a rapid acting, potent drug to reduce acidity of the gastric contents in conditions of acid hypersecretion.
在为完整麻醉大鼠的pH值滴定法改良的闭路灌注胃制备模型中，比较了铝碳酸镁（水合铝镁羟基碳酸盐，Al2Mg6(OH)14(CO3)2·4H2O，Almax）和氢氧化铝中和组胺诱导的胃酸分泌过多的效果。静脉注射组胺（0.75毫克/千克）后，在60分钟内测量为使胃灌注液维持在pH 4而自动添加到封闭系统中的抗酸剂的量。所得结果表明，在该胃酸分泌过多模型中，铝碳酸镁的酸中和能力约为氢氧化铝的8倍。对所得滴定曲线的分析还表明，实验开始时铝碳酸镁中和至pH 4的速度要快得多。得出的结论是，在胃酸分泌过多的情况下，铝碳酸镁将是一种速效、强效的降低胃内容物酸度的药物。
