Catterall M, Blake P R, Rampling R P
Br Med J (Clin Res Ed). 1984 Dec 15;289(6459):1653-5. doi: 10.1136/bmj.289.6459.1653.
Thirty one patients with very advanced tumours of the maxillary sinus were treated with fast neutrons. Tumour regressed completely in 29 (94%) and subsequently recurred in four (14%). No surgical excision of bone, skin, or nerve was required, and an artificial eye was well tolerated in cases where the eye received the tumour dose and had to be removed. Complications occurred in 10 patients, two of whom had already received radical x ray treatment. The overall duration of neutron treatment was four weeks, and admission to hospital was usually unnecessary. These results compared well with those obtained with surgery. Surgery with curative intent for even moderately advanced tumours of the facial region, particularly the paranasal sinuses, results in deformity, which is often severe and always irreversible. Even so, the cure rate is only about 35%. The high rates of tumour control and the avoidance of severe cosmetic and functional defects after fast neutron treatment make it an alternative to radical surgery in the management of malignant tumours of the facial area.
31例上颌窦极晚期肿瘤患者接受了快中子治疗。29例（94%）肿瘤完全消退，随后4例（14%）复发。无需进行骨、皮肤或神经的手术切除，在眼部接受肿瘤剂量且必须摘除的病例中，义眼耐受性良好。10例患者出现并发症，其中2例此前已接受过根治性放疗。中子治疗的总疗程为4周，通常无需住院。这些结果与手术治疗的结果相比良好。对面部区域甚至中度晚期肿瘤（尤其是鼻窦肿瘤）进行根治性手术会导致畸形，这种畸形往往很严重且总是不可逆的。即便如此，治愈率也仅约为35%。快中子治疗后肿瘤控制率高，且避免了严重的美容和功能缺陷，使其成为面部恶性肿瘤治疗中根治性手术的替代方法。
