Errington R D
Bull Cancer. 1986;73(5):569-76.
The poor prognosis of paranasal sinus carcinoma relates to its often late and advanced presentation. There are difficulties in achieving local control of the tumour and improving the quality and duration of survival with combinations of surgery and megavoltage radiotherapy. In this series of 43 patients with advanced sinus tumours treated with neutrons, the median survival was 33 months with a 75% local control rate. At 5 years the local control rate was 50% with 30% surviving. The complication rate was 5% at 12 months rising to 30% by 27 months with no further increase after this. The possible benefits of neutron therapy in treating the advanced tumours are discussed. Despite the disadvantages of low energy (7.5 MeV) neutron beams and the poor general condition of many of the patients in this series and the advanced nature of their tumours, a high local tumour control rate was observed and major facial surgery avoided.
鼻窦癌预后较差，这与其常常出现较晚且病情进展有关。通过手术和兆伏级放疗联合治疗，在实现肿瘤局部控制以及提高生存质量和延长生存期方面存在困难。在这组43例接受中子治疗的晚期鼻窦肿瘤患者中，中位生存期为33个月，局部控制率为75%。5年时局部控制率为50%，30%的患者存活。12个月时并发症发生率为5%，到27个月时升至30%，此后未再进一步增加。本文讨论了中子治疗在治疗晚期肿瘤方面可能带来的益处。尽管该组使用的低能量（7.5兆电子伏特）中子束存在缺点，且许多患者的一般状况较差以及肿瘤病情较晚，但仍观察到较高的局部肿瘤控制率，并且避免了大型面部手术。
