Butlin A T, Danta G, Cook M L
Clin Exp Neurol. 1984;20:27-35.
The effects of different drugs on memory function in epileptic patients were examined. Patients had clinically normal cognitive function, above average IQs and infrequent seizures. Compared with pre-treatment evaluation, treatment with phenytoin, but not with carbamazepine or sodium valproate, resulted in impaired memory performance after three months of treatment. Switching patients previously treated with phenytoin to carbamazepine resulted in an improvement in memory performance compared with that of patients remaining on phenytoin. Switching patients from carbamazepine to sodium valproate did not result in any change in performance compared with that of those remaining on carbamazepine. The results of these experiments suggest that phenytoin, but not carbamazepine or sodium valproate, causes impaired memory performance. The nature of the memory dysfunction and its clinical implications are discussed.
研究了不同药物对癫痫患者记忆功能的影响。患者临床认知功能正常，智商高于平均水平且癫痫发作不频繁。与治疗前评估相比，苯妥英钠治疗三个月后导致记忆表现受损，而卡马西平或丙戊酸钠治疗则未出现这种情况。将先前接受苯妥英钠治疗的患者换用卡马西平后，与继续使用苯妥英钠的患者相比，记忆表现有所改善。将患者从卡马西平换用丙戊酸钠后，与继续使用卡马西平的患者相比，记忆表现没有任何变化。这些实验结果表明，导致记忆表现受损的是苯妥英钠，而非卡马西平或丙戊酸钠。文中讨论了记忆功能障碍的性质及其临床意义。
