“脾功能亢进”大鼠红细胞的滤过性

Filtrability of erythrocytes in "hypersplenic" rats.

作者信息

Brabec V

出版信息

Folia Haematol Int Mag Klin Morphol Blutforsch. 1976;103(4):552-8.

Abstract

The values of haemoglobin, reticulocytes and half-times of the filtrability of non-washed and washed erythrocytes were examined in male albino rats, Wistar strain, after i.p. injections of methylcellulose (MC) and compared with controls. In individual experiments the rats received 2 to 32 injections of MC. In injected animals, the filtrability of non-washed erythrocytes was altered. The filtrability half-times of the washed erythrocytes did not differ from the controls. Thus, the filtrability is altered for extracorpuscular reasons. "Hypersplenism" being completely developed, (after 32 MC injections), the filtrability of non-washed erythrocytes repaired when the application of MC had been discontinued, the reticulocyte values remained however increased. Problems of the mechanism of anaemia in experimental "hypersplenism" after MC injections in rats and relations between the altered filtrability of the erythrocytes and the haemolysis are discussed.

摘要

对雄性Wistar品系白化大鼠腹腔注射甲基纤维素（MC）后，检测其血红蛋白、网织红细胞值以及未洗涤和洗涤红细胞滤过性的半衰期，并与对照组进行比较。在个别实验中，大鼠接受2至32次MC注射。在注射动物中，未洗涤红细胞的滤过性发生改变。洗涤红细胞的滤过性半衰期与对照组无差异。因此，滤过性改变是由于细胞外因素。在“脾功能亢进”完全发展后（32次MC注射后），停止应用MC时，未洗涤红细胞的滤过性恢复，但网织红细胞值仍升高。讨论了大鼠注射MC后实验性“脾功能亢进”中贫血的机制问题以及红细胞滤过性改变与溶血之间的关系。