Buvat J, Buvat-Herbaut M, Lemaire A, Racadot A, Fourlinnie J C
Horm Res. 1984;20(4):224-30. doi: 10.1159/000180001.
Plasma estradiol (E2), serum LH and FSH, and the gonadotropin response to two consecutive LHRH administrations (10 and 100 micrograms with an interval of 2 h) were determined in 19 patients with anorexia nervosa (AN) at the emaciation phase, before and after estradiol benzoate (E2B) injections (3 micrograms/kg/day for 7 days). The same investigations were repeated after weight restoration in 9 AN patients who remained amenorrheic. Both at the emaciation phase and after weight restoration, E2B enhanced the second LH response to LHRH and decreased serum FSH, suggesting that the functional capacities of the pituitary gonadotrophs are normal in AN. Unlike E2B injections, weight restoration increased all the hormone values, suggesting that the weight restoration effects on the abnormal gonadotropin secretory pattern of AN depend on another mechanism than the E2 lowering. That mechanism is probably a disorder of the hypothalamic LHRH secretion, the consequences of which could be reinforced by the low E2 levels.
在19例处于消瘦期的神经性厌食症（AN）患者中，于苯甲酸雌二醇（E2B）注射前及注射后（3微克/千克/天，共7天），测定血浆雌二醇（E2）、血清促黄体生成素（LH）和促卵泡生成素（FSH），以及对连续两次注射促性腺激素释放激素（LHRH）（10微克和100微克，间隔2小时）的促性腺激素反应。对9例体重恢复后仍闭经的AN患者重复进行相同检查。在消瘦期及体重恢复后，E2B均增强了LH对LHRH的第二次反应，并降低了血清FSH，提示AN患者垂体促性腺细胞的功能能力正常。与E2B注射不同，体重恢复使所有激素值升高，表明体重恢复对AN异常促性腺激素分泌模式的影响依赖于不同于降低E2的另一种机制。该机制可能是下丘脑LHRH分泌紊乱，低E2水平可能会加重其后果。
