Kovacic B, Domino E F
Psychopharmacology (Berl). 1984;84(3):310-4. doi: 10.1007/BF00555204.
Five Cebus apella monkeys were treated with biweekly injections of fluphenazine enanthate (0.1-3.2 mg/kg IM). Three of these completed 1 full year of treatment, one injured its leg after 6 months of treatment and was killed, and another died of unknown causes after 9 months of treatment. All monkeys displayed abnormal movements corresponding to the early appearing extrapyramidal symptoms of neuroleptic-treated patients. These consisted initially of slowing or absence of volitional movement, trembling of the hands, trembling of the entire body, and general drowsy behavior. As treatment progressed, a variety of abnormal postures and movements appeared after each injection that were not exacerbated by drug withdrawal and, as tested at the end of the year, could be abolished or prevented with benztropine mesylate (0.2-0.5 mg/kg IM). The three monkeys that completed 1 year of treatment with fluphenazine were then withdrawn from the drug. After withdrawal, all three developed movements similar in appearance to those of patients with tardive dyskinesia (TD). Reinstitution of fluphenazine treatment, as tested in one monkey, abolished all movements resembling TD.
五只卷尾猴接受了每两周一次的庚酸氟奋乃静注射（0.1 - 3.2毫克/千克，肌肉注射）。其中三只完成了一整年的治疗，一只在治疗6个月后腿部受伤并被处死，另一只在治疗9个月后死于不明原因。所有猴子都表现出与接受抗精神病药物治疗的患者早期出现的锥体外系症状相对应的异常运动。这些症状最初包括随意运动减慢或缺失、手部颤抖、全身颤抖以及普遍的嗜睡行为。随着治疗的进展，每次注射后都会出现各种异常姿势和运动，停药后这些症状不会加重，并且在年底测试时，可通过甲磺酸苯扎托品（0.2 - 0.5毫克/千克，肌肉注射）消除或预防。然后，对完成了一年庚酸氟奋乃静治疗的三只猴子停药。停药后，所有三只猴子都出现了与迟发性运动障碍（TD）患者相似的运动。在一只猴子身上进行测试时，重新使用庚酸氟奋乃静治疗消除了所有类似TD的运动。
