See R E, Ellison G
Department of Psychology, University of California, Los Angeles 90024.
Psychopharmacology (Berl). 1990;100(3):404-12. doi: 10.1007/BF02244615.
Rats were administered equivalent doses of haloperidol for either 28 days or 8 months using one of two different drug regimens: intermittent (i.e., weekly injections) or continuously (via drinking water and osmotic mini-pumps). Oral movements were determined by human observers and by a computerized video analysis system, which determined number and amplitude of jaw openings and closings (computer-scored movelets "CSMs") as well as the slope (amplitude/duration) and frequency spectrum (fourier transform) of oral activity. The two drug groups developed distinctively different changes over time. Continuous administration resulted in late-onset oral activity changes at 1-3 Hz and withdrawal increases in CSMs, a pattern expected of tardive dyskinesia. Intermittent treatment produced a primed dystonia-like pattern: large amplitude CSMs which had steep onset slopes and a peak energy at 4-7 Hz. These results demonstrate the importance of drug regimen in determining the type of neuroleptic-induced dyskinesias which develop with prolonged neuroleptic treatment in rodents.
使用两种不同给药方案之一，给大鼠连续28天或8个月给予等效剂量的氟哌啶醇：间歇性给药（即每周注射）或持续给药（通过饮用水和渗透微型泵）。由人类观察者和计算机化视频分析系统测定口腔运动，该系统测定颌部张开和闭合的次数及幅度（计算机评分的微动作“CSMs”）以及口腔活动的斜率（幅度/持续时间）和频谱（傅里叶变换）。随着时间推移，两个药物组出现了明显不同的变化。持续给药导致在1 - 3 Hz出现迟发性口腔活动变化以及撤药后CSMs增加，这是迟发性运动障碍预期的模式。间歇性治疗产生了一种类似启动性肌张力障碍的模式：具有陡峭起始斜率且在4 - 7 Hz有能量峰值的大幅度CSMs。这些结果证明了给药方案在确定啮齿动物长期使用抗精神病药物治疗时所发生的抗精神病药物诱发的运动障碍类型方面的重要性。
