Rönnberg L, Ylöstalo P, Järvinen P A
Postgrad Med J. 1979;55 Suppl 5:21-6.
Twenty patients, mostly with severe endometriosis and infertility, were treated with danazol 600 mg daily for six months. Clinical investigation and laboratory tests were done monthly. During treatment most clinical findings and symptoms of endometriosis disappeared within 2 to 3 months, but rectocervical induration and rectocervical pain decreased more slowly. During the 10 months follow-up after discontinuation of danazol, dysmenorrhoea recurred most commonly of all symptoms, but not to the same degree as before treatment and the patients were mainly satisfied. Gonadotrophin and prolactin levels did not alter significantly during treatment. Serum oestradiol and progesterone values were low during the danazol course. Testosterone values increased because of cross-reaction with danazol metabolites in the testosterone assay. Serum transaminase, creatinine, haemoglobin and blood platelet concentrations increased on average, but the changes were reversible. Three conceptions occurred during the period of study.
20名患者，多数患有严重子宫内膜异位症且不孕，接受了每日600毫克达那唑治疗，为期6个月。每月进行临床检查和实验室检测。治疗期间，多数子宫内膜异位症的临床体征和症状在2至3个月内消失，但直肠宫颈硬结和直肠宫颈疼痛缓解较慢。在停用达那唑后的10个月随访期间，痛经是所有症状中最常复发的，但程度不如治疗前，患者总体较为满意。治疗期间促性腺激素和催乳素水平无显著变化。达那唑疗程中血清雌二醇和孕酮值较低。由于睾酮检测中与达那唑代谢产物的交叉反应，睾酮值升高。血清转氨酶、肌酐、血红蛋白和血小板浓度平均升高，但这些变化是可逆的。研究期间有3例怀孕。
