Ucer U, Spengler M
Andrologia. 1984 Nov-Dec;16(6):559-67. doi: 10.1111/j.1439-0272.1984.tb00413.x.
The biological and immunological activities of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in the serum of infertile males were determined by radioreceptor (RRA) and radioimmunoassay (RIA), respectively. In some sera the biological activity of serum LH was lower than expected on the basis of the RIA-data. In contrast, some sera contained unusually high levels of biologically active LH as demonstrated by RRA, despite not being detected in these amounts by RIA. Prolonged exposure of the gonad to such high levels of biologically active LH might cause end-organ desensitization resulting in infertility. The detection of such cases by the use of RRA could permit therapy in these individuals or exclude patients from treatment.
分别采用放射受体分析法（RRA）和放射免疫分析法（RIA）测定了不育男性血清中促黄体生成素（LH）和促卵泡生成素（FSH）的生物学活性及免疫活性。在某些血清中，血清LH的生物学活性低于根据放射免疫分析数据预期的水平。相反，尽管放射免疫分析未检测到这些量，但放射受体分析法显示，某些血清中含有异常高水平的具有生物活性的LH。性腺长时间暴露于如此高水平的具有生物活性的LH可能会导致终末器官脱敏，从而导致不育。通过使用放射受体分析法检测此类病例，可以对这些个体进行治疗或将患者排除在治疗之外。
