Gibelin P, Rainart J P, Aubran M, Camous J P, Morand P
Arch Mal Coeur Vaiss. 1984 Dec;77(13):1502-9.
Cardiac failure is usually defined according to clinical and haemodynamic criteria at rest although these patients are mainly symptomatic on effort. Is it possible to substitute or associate a more "objective" method to the NYHA functional classification such as exercise stress testing? If so, is there a correlation between these two types of classification and resting haemodynamic data; have they any predictive value of the patient's exercise capacity? Twenty two patients with severe cardiac failure (Class III or IV of the NYHA), 18 men and 4 women with a mean age of 58 years, underwent a triangular exercise stress test on a bicycle ergometer to 80 p. 100 or more of their theoretical maximal heart rate. The ergometric parameters chosen for the study were the maximal oxygen consumption or its value when limited by symptoms, the maximal work with respect to weight, the total duration of exercise and the percentage increase in systolic blood pressure. The haemodynamic parameters chosen were pulmonary capillary pressure, systolic index, ejection fraction and the velocity of circumferential fibre shortening. No correlation was found between the NYHA functional class and exercise capacity. A dissociated correlation was observed between exercise capacity and resting haemodynamic data. The best correlation was between systolic index and exercise capacity (work performed corrected for body weight, r = 0.70, p less than 0.01; oxygen consumption, r = 0.60, p less than 0.01). After one month of treatment with a vasodilator (Prazosin) in 10 patients, the duration of exercise increased by 2.2 +/- 0.5 min.(ABSTRACT TRUNCATED AT 250 WORDS)
心力衰竭通常是根据静息状态下的临床和血流动力学标准来定义的,尽管这些患者主要在运动时出现症状。是否有可能用一种更“客观”的方法替代纽约心脏协会(NYHA)功能分级或与之联合使用,比如运动压力测试?如果可以,这两种分级与静息血流动力学数据之间是否存在相关性;它们对患者的运动能力有无预测价值?22例重度心力衰竭患者(NYHA分级为III级或IV级),18名男性和4名女性,平均年龄58岁,在自行车测力计上进行了三角运动压力测试,达到其理论最大心率的80%、100%或更高。本研究选择的测力计参数为最大耗氧量或受症状限制时的耗氧量值、相对于体重的最大工作量、运动总时长以及收缩压的增加值。选择的血流动力学参数为肺毛细血管压、收缩指数、射血分数和圆周纤维缩短速度。未发现NYHA功能分级与运动能力之间存在相关性。观察到运动能力与静息血流动力学数据之间存在分离的相关性。收缩指数与运动能力之间的相关性最佳(根据体重校正的工作量,r = 0.70,p < 0.01;耗氧量,r = 0.60,p < 0.01)。10例患者接受血管扩张剂(哌唑嗪)治疗1个月后,运动时长增加了2.2 +/- 0.5分钟。(摘要截取自250字)