血小板激活因子对人血小板花生四烯酸代谢的影响。
The influence of PAF on the metabolization of arachidonic acid by human blood platelets.
作者信息
Ostermann G, Block H U, Till U
出版信息
Biomed Biochim Acta. 1984;43(8-9):S323-6.
PMID:6440547
Abstract
The cooperative action of PAF and arachidonic acid, collagen or the divalent cation ionophore A 23 187 was studied in human platelet-rich plasma. Besides an augmentation of the platelet aggregation also increased amounts of thromboxane B2 and malondialdehyde are generated. Both effects are inhibited by aspirin indicating that the cyclooxygenase pathway plays a major role in the synergistic platelet activation.
摘要
在富含人血小板的血浆中研究了血小板活化因子（PAF）与花生四烯酸、胶原蛋白或二价阳离子载体A 23187的协同作用。除了增强血小板聚集外，还会生成增加量的血栓素B2和丙二醛。这两种效应均被阿司匹林抑制，表明环氧化酶途径在协同性血小板活化中起主要作用。
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