Fitscha P, Kaliman J, Sinzinger H
Biomed Biochim Acta. 1984;43(8-9):S403-8.
Platelet labeling with 111-In-oxinesulfate allows visualization of platelet deposition in the vascular bed. Scintigraphic studies were performed in 6 patients with "active" (PUR greater than 1.20) and 8 patients with "inactive" (PUR less than 1.20) atherosclerotic lesions of the femoral artery. Platelet deposition was also studied in 11 patients with implanted prosthetic vascular grafts and in 21 patients with an abnormal aneurysm of the aorta. Infusing 5 ng/kg/min PGI2 during 6 hours for 5 days into patients with "active"-atherosclerosis and aneurysms of the aorta resulted in a significant decrease of platelet deposition even after having stopped the infusion. There was no influence of PGI2 on PUR in patients with "inactive" lesions. The group of patients with implanted prosthetic grafts demonstrated also a significant decrease of PUR values during the PGI2-infusion, but reached baseline values soon after stopping the infusion. When platelet deposition is increased gamma-camera imaging provides valuable date on the influence of any kind of therapy on the in-vivo platelet function.
用111-铟-氧肟酸盐标记血小板可使血管床中的血小板沉积可视化。对6例患有“活动性”（PUR大于1.20）股动脉粥样硬化病变的患者和8例患有“非活动性”（PUR小于1.20）股动脉粥样硬化病变的患者进行了闪烁扫描研究。还对11例植入人工血管移植物的患者和21例主动脉异常动脉瘤患者的血小板沉积情况进行了研究。对患有“活动性”动脉粥样硬化和主动脉瘤的患者，连续5天每天6小时输注5 ng/kg/min的前列环素（PGI2），即使在停止输注后，血小板沉积也显著减少。PGI2对患有“非活动性”病变的患者的PUR没有影响。植入人工血管移植物的患者组在输注PGI2期间PUR值也显著降低，但在停止输注后很快恢复到基线值。当血小板沉积增加时，γ相机成像可为任何治疗对体内血小板功能的影响提供有价值的数据。
