Pramsohler B, Lupattelli G, Scholz H, Sinzinger H
Department of Neurology, Hospital Villach, Austria.
Prog Clin Biol Res. 1990;355:71-80.
In the present study the prevalence of active atherosclerotic lesion sites in the carotid and femoral arteries as well as the platelet survival in a selected group of 33 patients (8 males, 25 females) below the age of 50 after juvenile stroke has been examined. In the patients studied a high frequency (80%) of positive (visible) carotid artery lesions with a platelet uptake ratio (PUR) ranging from 1.07-1.79 as well as an extremely shortened platelet survival were monitored. In-vitro platelet function tests, however, did not show significant abnormalities. No correlation between PUR, platelet survival, platelet function and the clinical situation could be assessed. These findings indicate that in this highly selected group of patients in-vivo haemostatic balancing seems to be severely impaired.
在本研究中，对33例年龄在50岁以下的青少年卒中患者（8例男性，25例女性）组成的特定组进行了检查，观察其颈动脉和股动脉中活动性动脉粥样硬化病变部位的患病率以及血小板存活情况。在所研究的患者中，监测到高频（80%）的阳性（可见）颈动脉病变，血小板摄取率（PUR）在1.07 - 1.79之间，以及血小板存活时间极短。然而，体外血小板功能测试未显示明显异常。无法评估PUR、血小板存活、血小板功能与临床情况之间的相关性。这些发现表明，在这一经过高度挑选的患者组中，体内止血平衡似乎受到严重损害。
