Pope H G, Hudson J I, Poskanzer D C, Yurgelun-Todd D
Biol Psychiatry. 1984 Oct;19(10):1449-59.
Familial hyperkalemic periodic paralysis and bipolar disorder are both hereditary disorders, characterized by episodes of illness separated by periods of remission, and possibly related to abnormalities in cellular ion transport. Recently we discovered a patient who suffered from both illnesses, as did his mother and grandmother. However, a detailed investigation of the pedigree suggested that these two disorders are not linked genetically. Furthermore, a placebo-controlled double-blind trial of lithium carbonate in this patient found lithium ineffective in preventing the attacks of paralysis, in contrast to another recent study which found lithium effective in hypermagnesemic periodic paralysis.
家族性高钾性周期性麻痹和双相情感障碍均为遗传性疾病，其特征为疾病发作期与缓解期交替出现，且可能与细胞离子转运异常有关。最近我们发现了一位同时患有这两种疾病的患者，他的母亲和祖母也患有同样的疾病。然而，对该家族谱系的详细调查表明，这两种疾病在基因上并无关联。此外，对该患者进行的碳酸锂安慰剂对照双盲试验发现，与另一项近期研究发现碳酸锂对高镁血症性周期性麻痹有效相反，碳酸锂对预防麻痹发作无效。
