Holt S, Wilkinson A, Suresh M R, Mate G, Reid W B, Longenecker B M, McPherson A, Noujaim A A
Cancer Lett. 1984 Nov;25(1):55-60. doi: 10.1016/s0304-3835(84)80026-9.
To investigate the role of intravenously administered, radioiodinated peanut lectin (131I-PNA) in the non-invasive detection of cancer, the pharmacokinetics and scintigraphic distribution of this novel tumor-seeking compound were studied in 8 patients with metastatic cancer of the colon, breast or lung. Scintigraphic localization of 131I-PNA was apparent at certain anatomical sites of known metastases in 2 patients and in a further 2 patients an adjacent malignant pleural effusion was visualized. The rapid clearance of radioactivity from the whole body and plasma with marked renal concentration and rapid urinary excretion of significant amounts of intact 131I-PNA (mol. wt. 107,000, pI 5.95) implied that this molecule was excreted selectively by the renal tubules. PNA or other lectins may find a role in the scintigraphic detection of selected types of cancer.
为了研究静脉注射放射性碘化花生凝集素（¹³¹I-PNA）在癌症无创检测中的作用，我们对8例患有结肠、乳腺或肺癌转移的患者进行了研究，观察了这种新型肿瘤靶向化合物的药代动力学和闪烁扫描分布情况。在2例患者已知转移灶的特定解剖部位可见¹³¹I-PNA的闪烁扫描定位，另外2例患者可见相邻的恶性胸腔积液显影。放射性物质从全身和血浆中快速清除，肾脏有明显浓聚，大量完整的¹³¹I-PNA（分子量107,000，等电点5.95）快速经尿液排泄，这表明该分子是由肾小管选择性排泄的。PNA或其他凝集素可能在特定类型癌症的闪烁扫描检测中发挥作用。
