Factor VIII competitive enzyme assay: observations in von Willebrand's variants and hemophiliacs.

The competitive enzyme-linked immunoassay (CELIA) was used to quantitate factor VIII antigen in plasma from 24 patients with von Willebrand's disease (VWD), VWD variant or hemophilia A. This demonstration of CELIA's clinical usefulness is significant because the simplicity and efficiency of the technique make it suitable for use in many health-related institutions regardless of size or sophistication.