Shaaban M M, Elwan S I, el-Sharkawy M M, Farghaly A S
Contraception. 1984 Nov;30(5):407-12. doi: 10.1016/0010-7824(84)90032-5.
Forty-seven normal health women were studied longitudinally for changes in liver functions during the use of the levonorgestrel contraceptive implant system, NORPLANT. Samples were collected before insertion of the implants and after one, three and six months of use. The enzymes studied were the transaminases (SGOT and SGPT), alkaline phosphatase and gamma-glutamyl transferase. Serum bilirubin and bile acid levels were also measured. The protein synthetic function of the liver was tested by estimation of total proteins, albumin, transferrin, hemopexin, ceruloplasmin and haptoglobin. The three main immunoglobulins, G, M and A, were also measured. There were no significant changes in the liver enzymes after NORPLANT use. Serum bilirubin and bile acid concentrations showed rises in the first month of use which ameliorated in subsequent months. Serum albumin was transiently increased during the first and third months. Ceruloplasmin decreased significantly at the sixth month. The concentrations of total serum proteins and the other individual proteins showed no significant change. The results point to safety of NORPLANT implant use, as regards hepatic functions.
对47名健康女性进行了纵向研究，以观察她们在使用左炔诺孕酮避孕植入系统（诺普兰）期间肝功能的变化。在植入前以及使用1个月、3个月和6个月后采集样本。所研究的酶包括转氨酶（谷草转氨酶和谷丙转氨酶）、碱性磷酸酶和γ-谷氨酰转移酶。还测量了血清胆红素和胆汁酸水平。通过估算总蛋白、白蛋白、转铁蛋白、血红素结合蛋白、铜蓝蛋白和触珠蛋白来检测肝脏的蛋白质合成功能。还测量了三种主要免疫球蛋白G、M和A。使用诺普兰后，肝脏酶没有显著变化。血清胆红素和胆汁酸浓度在使用的第一个月有所升高，在随后几个月有所改善。血清白蛋白在第一个月和第三个月短暂升高。铜蓝蛋白在第六个月显著下降。血清总蛋白和其他个体蛋白的浓度没有显著变化。结果表明，就肝功能而言，使用诺普兰植入物是安全的。
