Hunt D R, Lane H W, Beesinger D, Gallagher K, Halligan R, Johnston D, Rowlands B J
JPEN J Parenter Enteral Nutr. 1984 Nov-Dec;8(6):695-9. doi: 10.1177/0148607184008006695.
Victims of major burns may be at risk for selenium (Se) depletion because increased postinjury nutrient needs are often met by total parental nutrition and tube feedings which contain little Se. This study compared Se status of 17 burn patients and 191 healthy control subjects. Se intake of burn patients was lower than the intake of control subjects when total parenteral nutrition or tube feedings were used as primary nutrient sources but was comparable to the control intake when burn patients consumed oral diets. Serial determinations each 10 days during recovery showed that burn patients had lower plasma Se, erythrocyte Se, and erythrocyte glutathione peroxidase levels, and lower 24-hr urine Se excretion. These results provide biochemical evidence of Se depletion despite exogenous Se intake within the range recommended for healthy adults. Further studies are indicated to determine if Se depletion in burn patients can be prevented by Se supplementation of total parenteral nutrition and tube feeding solutions.
大面积烧伤患者可能存在硒（Se）缺乏风险，因为受伤后营养需求增加，通常通过几乎不含硒的全胃肠外营养和管饲来满足。本研究比较了17例烧伤患者和191例健康对照者的硒状态。当以全胃肠外营养或管饲作为主要营养来源时，烧伤患者的硒摄入量低于对照组，但当烧伤患者经口进食时，其硒摄入量与对照组相当。恢复期间每10天进行的连续测定显示，烧伤患者的血浆硒、红细胞硒和红细胞谷胱甘肽过氧化物酶水平较低，24小时尿硒排泄量也较低。这些结果提供了生化证据，表明尽管外源性硒摄入量在健康成年人推荐范围内，但烧伤患者仍存在硒缺乏。建议进一步研究以确定补充全胃肠外营养和管饲溶液中的硒是否可预防烧伤患者的硒缺乏。
