Giani E, Masi I, Colombo C, Galli C
Prostaglandins. 1984 Oct;28(4):573-86. doi: 10.1016/0090-6980(84)90245-4.
Sex differences in eicosanoid production in platelets and vessel walls have been studied in control and n-6 fatty acid supplemented rats. In platelet rich plasma (PRP) of control female rats, arachidonic acid (AA) levels in phospholipids (PL), thromboxane B2 (TxB2) formation following collagen stimulation and aggregatory responses to collagen were higher than in PRP of male rats. 6 keto PGF1 alpha release from PRP-perfused isolated aortas were the same for both sexes, but the antiaggregatory activity of the wall was higher in males than in females, in association with a greater sensitivity of male platelets to prostacyclin. The administration of n-6 fatty acid supplements increased AA level in PL, TxB2 production and aggregation only in male platelets. Production of 6 keto PGF1 alpha and the antiaggregatory activity of aortic walls were reduced after dietary treatment in males, but biochemical and functional parameters were not correlated in females. The results indicate complex sex-related differences in fatty acid metabolism and eicosanoid production, and in responses to n-6 dietary fatty acids in platelets and the vascular system in the rat.
在对照大鼠和补充了n-6脂肪酸的大鼠中，对血小板和血管壁中类花生酸生成的性别差异进行了研究。在对照雌性大鼠的富含血小板血浆（PRP）中，磷脂（PL）中的花生四烯酸（AA）水平、胶原刺激后血栓素B2（TxB2）的形成以及对胶原的聚集反应均高于雄性大鼠的PRP。两性从PRP灌注的离体主动脉中释放的6-酮-前列环素F1α相同，但雄性血管壁的抗聚集活性高于雌性，这与雄性血小板对前列环素的敏感性更高有关。补充n-6脂肪酸仅增加了雄性血小板中PL的AA水平、TxB2生成和聚集。饮食处理后，雄性大鼠主动脉壁的6-酮-前列环素F1α生成和抗聚集活性降低，但雌性大鼠的生化和功能参数无相关性。结果表明，在大鼠的血小板和血管系统中，脂肪酸代谢、类花生酸生成以及对n-6膳食脂肪酸的反应存在复杂的性别相关差异。
