Tremoli E, Socini A, Petroni A, Galli C
Prostaglandins. 1982 Sep;24(3):397-404. doi: 10.1016/0090-6980(82)90166-6.
The influences of experimental hypercholesterolemia in the rabbit on platelet-vessel wall interactions have been studied by evaluating the aggregatory response of platelet rich plasma (PRP) to arachidonic acid (AA) stimulation and levels of 6-keto-PGF1 alpha in PRP from normal (N) and hypercholesterolemic (HC) animals prior and after perfusion through the corresponding aortas. In addition, the responses of N PRP to aggregation after perfusion through HC aortas and those of HC PRP perfused through N aortas, and the platelet response to the inhibitory effect of exogenous prostacyclin have been evaluated. The data indicate that in HC rabbits, on one side platelets are hyperreactive to AA and less sensitive to the inhibitory activity of prostacyclin and, on the other, the antiaggregatory activity and prostacyclin production of vessel walls is higher, suggesting compensatory mechanisms in the haemostatic balance.
通过评估富含血小板血浆（PRP）对花生四烯酸（AA）刺激的聚集反应以及正常（N）和高胆固醇血症（HC）动物的PRP在通过相应主动脉灌注前后的6-酮-PGF1α水平，研究了兔实验性高胆固醇血症对血小板-血管壁相互作用的影响。此外，还评估了N PRP通过HC主动脉灌注后的聚集反应以及HC PRP通过N主动脉灌注后的聚集反应，以及血小板对外源性前列环素抑制作用的反应。数据表明，在HC兔中，一方面血小板对AA反应过度，对前列环素的抑制活性敏感性降低，另一方面血管壁的抗聚集活性和前列环素生成较高，提示止血平衡中的代偿机制。
