Kapa D, Biljanović-Paunović L, Milenković P, Pavlović-Kentera V
Acta Haematol. 1984;72(5):295-302. doi: 10.1159/000206405.
Splenic CFU-E in mice were determined during stimulation and suppression of erythropoiesis by means of the methylcellulose culture system originally used for bone marrow CFU-E. It was found that under steady-state conditions the number of CFU-E in the spleen comprises less than 20% of the CFU-E in the total bone marrow mass. The number of CFU-E decreased with suppression and increased after stimulation of erythropoiesis. The response to exogenous Ep stimulation on day 10 posthypoxia was more pronounced in the spleen than in the bone marrow (the number of CFU-E was 1.6 times greater in the spleen than in the total bone marrow mass) indicating the importance of the spleen in stimulated erythropoiesis in mice.
利用最初用于骨髓CFU-E的甲基纤维素培养系统，在小鼠红细胞生成的刺激和抑制过程中测定脾脏CFU-E。发现在稳态条件下，脾脏中CFU-E的数量占总骨髓质量中CFU-E数量的不到20%。红细胞生成受到抑制时CFU-E数量减少，受到刺激后则增加。低氧后第10天，脾脏对外源性促红细胞生成素（Ep）刺激的反应比骨髓更明显（脾脏中CFU-E的数量比总骨髓质量中的多1.6倍），这表明脾脏在小鼠受刺激的红细胞生成中具有重要作用。
