Pavlović-Kentera V, Susić D, Biljanović-Paunović L, Milenkoviĉ P
Haematologia (Budap). 1984;17(2):161-8.
PG synthesis inhibitors were used to study the role of PG in modulating Ep effects on erythroid progenitors. The stimulating effect of exogenous Ep on both 59Fe incorporation into RBC and CFU-E number in polycythaemic mice was inhibited with indomethacin and aspirin treatment during the posthypoxic period. The inhibitory effect of indomethacin on CFU-E derived colonies was demonstrated only when cultured bone marrow and spleen cells were obtained from mice stimulated by prolonged exposure to hypoxia. The results implicate the role of PG in the Ep dependent regulation of the erythroid progenitor cell compartment size and Ep responsiveness in vivo.
前列腺素（PG）合成抑制剂被用于研究PG在调节促红细胞生成素（Ep）对红系祖细胞作用中的角色。在缺氧后时期，用吲哚美辛和阿司匹林处理可抑制外源性Ep对红细胞增多症小鼠59Fe掺入红细胞以及集落形成单位-红细胞（CFU-E）数量的刺激作用。仅当从长期暴露于缺氧刺激的小鼠获取培养的骨髓和脾细胞时，才证实吲哚美辛对CFU-E衍生集落有抑制作用。这些结果提示PG在体内Ep依赖的红系祖细胞区室大小调节和Ep反应性中发挥作用。
