Björkeland M, Boivie J
Anat Embryol (Berl). 1984;170(3):265-77. doi: 10.1007/BF00318730.
The projections to the midbrain from the spinal cord have been investigated in the cat with the degeneration technique and by using horseradish peroxidase (HRP) as an anterograde tracer. Two types of spinal cord lesions were performed: 1) Cordotomies at cervical or thoracic levels transecting the ventral and lateral funiculi. 2) Transections of the ventral, ventrolateral, dorsolateral or dorsal funiculus, respectively, at cervical levels. In the anterograde tracing experiments HRP was injected into the spinal cord at cervical, lumbar or sacral levels. The results show large projections to the lateral and ventrolateral parts of the periaqueductal gray (PAG1), the posterior pretectal nucleus (PP) and the nucleus of Darkschewitsch (D). More moderate projections go to the medial division of the periaqueductal gray (PAGm), the cuneiform nucleus (CF), the mesencephalic reticular formation (MRF), lateral part of the deep layer of the superior colliculus (SP) and magnocellular medial geniculate nucleus (GMmc), while scattered spinal fibers are present in the dorsal part of the periaqueductal gray (PAGd), the external inferior collicular nucleus (IX), the intermediate layer of the superior colliculus (SI), the lateral part of the red nucleus (NR) and in the Edinger-Westphal portion of the oculomotor nucleus (3). In addition a few fibers are present in the interstitial nucleus of Cajal (CA) and anterior pretectal nucleus (PAc). The results indicate that at midcervical levels most of the spinomesencephalic fibers ascend in the ventral funiculus, with only a moderate fraction ascending in the ventral half of the lateral funiculus. Almost no fibers ascend in the dorso-lateral funiculus and none appear to pass in the dorsal funiculus. No distinct somatotopic pattern was found in the spinomesencephalic projections, but more fibers from cervicobrachial segments terminate in the rostral than in the caudal parts of the terminal fields in PAG, CF, SP and IX, while the lumbar fibers were more numberous in the caudal parts. PP seems to receive spinal fibers mainly from the caudal half of the cord.
利用变性技术并通过使用辣根过氧化物酶（HRP）作为顺行示踪剂，在猫身上研究了脊髓向中脑的投射。进行了两种类型的脊髓损伤：1）在颈段或胸段进行脊髓横切，切断腹侧和外侧索。2）分别在颈段切断腹侧、腹外侧、背外侧或背索。在顺行示踪实验中，将HRP注入颈段、腰段或骶段脊髓。结果显示，向导水管周围灰质（PAG1）的外侧和腹外侧部分、顶盖前核（PP）和达克谢维奇核（D）有大量投射。向导水管周围灰质内侧部（PAGm）、楔状核（CF）、中脑网状结构（MRF）、上丘深层外侧部（SP）和大细胞内侧膝状体核（GMmc）的投射较为适中，而在导水管周围灰质背侧部（PAGd）、下丘外侧核（IX）、上丘中间层（SI）、红核外侧部（NR）以及动眼神经核的埃丁格 - 韦斯特法尔部分（3）有散在的脊髓纤维。此外，在 Cajal 间质核（CA）和顶盖前核前部（PAc）也有少量纤维。结果表明，在颈中部水平，大多数脊髓中脑纤维在腹侧索中上行，只有一小部分在外侧索腹侧半部上行。几乎没有纤维在背外侧索中上行，也没有纤维似乎通过背索。在脊髓中脑投射中未发现明显的躯体定位模式，但来自颈臂段的纤维在PAG、CF、SP和IX终末场的头端比尾端终止的更多，而腰段纤维在尾端部分数量更多。PP似乎主要从脊髓尾侧半部接收脊髓纤维。
