Yezierski R P
Department of Anatomy, University of Mississippi Medical Center, Jackson 39216.
J Comp Neurol. 1988 Jan 1;267(1):131-46. doi: 10.1002/cne.902670109.
Anterograde transport of wheat germ agglutinin conjugated to horseradish peroxidase was used to determine the terminal domain of the projection from the lumbosacral spinal cord to the midbrain in the rat, cat, and monkey. Results have shown that several midbrain regions receiving afferent input from this level of the spinal cord are common to the three species examined. Structures innervated by this projection were located throughout the full rostrocaudal extent of the midbrain. The strongest projections were to the intercollicular region and caudal midbrain contralateral to injection sites in the spinal cord. Terminal labeling in the rostral midbrain, except that observed in the nucleus of Darkschewitsch, was substantially less than that observed at more caudal midbrain levels. Structures receiving the strongest input from the spinal cord included the central gray, nucleus cuneiformis, the deep and intermediate layers of the superior colliculus, and the intercollicular nucleus. Other structures receiving afferent input from the lumbosacral spinal cord included the anterior and posterior pretectal nuclei, red nucleus, Edinger-Westphal nucleus, interstitial nucleus of Cajal, and the mesencephalic reticular formation. It is concluded that the spinal projection to the midbrain is a multicomponent projection consisting of several pathways terminating in discrete midbrain regions. Considering the diverse functions associated with midbrain regions receiving spinal input and the response and receptive field properties of cells belonging to this pathway, the results of the present study are discussed in relation to the potential role of the spinomesencephalic tract in somatic, visceral, and motor function.
将与辣根过氧化物酶结合的小麦胚芽凝集素进行顺行运输，用于确定大鼠、猫和猴从腰骶脊髓到中脑的投射终末区域。结果表明，从脊髓这一水平接受传入输入的几个中脑区域在所研究的三个物种中是共有的。受该投射支配的结构位于中脑整个前后范围。最强的投射是到脊髓注射部位对侧的中脑间区域和尾侧中脑。除了在达克谢维奇核中观察到的以外，在中脑头端的终末标记明显少于在中脑更尾端水平观察到的。从脊髓接受最强输入的结构包括中央灰质、楔状核、上丘深层和中层以及中脑间核。从腰骶脊髓接受传入输入的其他结构包括前顶盖前核和后顶盖前核、红核、动眼神经副核、 Cajal间质核和中脑网状结构。得出的结论是，脊髓到中脑的投射是一种多成分投射，由终止于离散中脑区域的几条通路组成。考虑到与接受脊髓输入的中脑区域相关的多种功能以及属于该通路的细胞的反应和感受野特性，本研究结果就脊髓中脑束在躯体、内脏和运动功能中的潜在作用进行了讨论。
