Mourad G, Mimran A, Mion C
Arch Mal Coeur Vaiss. 1984 Oct;77(11):1247-50.
The response to acute isotonic saline loading (1 800 ml in 3 hours) was assessed in 12 normotensive and 11 hypertensive renal transplant recipients. Both groups had similar renal function, daily urinary excretion of sodium and doses of steroids. The natriuretic response to saline was not affected in hypertensive transplants and changes in blood pressure, renin and aldosterone were identical in both groups. Similar correlations between pre-saline fractional excretion of sodium (FENa+) and the FENa+ obtained during saline were obtained in normotensive and hypertensive patients. These results demonstrate that in renal transplant recipients of young donors no exaggeration of the response to saline occurs in hypertensive subjects thus suggesting that normal kidneys may carry their characteristics when transplanted in a new environment. The role of renal denervation remains unclear.
在12名血压正常和11名高血压肾移植受者中评估了对急性等渗盐水负荷（3小时内1800毫升）的反应。两组的肾功能、每日尿钠排泄量和类固醇剂量相似。高血压移植受者对盐水的利钠反应未受影响，两组的血压、肾素和醛固酮变化相同。血压正常和高血压患者在盐水负荷前的钠排泄分数（FENa+）与盐水负荷期间获得的FENa+之间存在相似的相关性。这些结果表明，在年轻供体的肾移植受者中，高血压患者对盐水的反应不会过度，因此表明正常肾脏在移植到新环境中时可能保留其特征。肾去神经支配的作用仍不清楚。
