一种新型多价假单胞菌疫苗。
A new polyvalent pseudomonas vaccine.
作者信息
Merle P, Robbel L, Hungerer K D
出版信息
Behring Inst Mitt. 1984 Nov(76):113-20.
PMID:6441560
Abstract
A new polyvalent Pseudomonas aeruginosa vaccine consisting of extracts of the 24 serotypes of the Lanyi typing scheme was developed and evaluated in mouse protection studies. The vaccine, mainly consisting of lipopolysaccharides and outer membrane proteins was protective in passive and active protection studies. A rabbit antiserum against the vaccine showed high protective capacity in the IgG-fraction and was protective against 3 out of 6 challenge strains in a leucopenic mouse model.
摘要
一种由兰伊分型方案的24种血清型提取物组成的新型多价铜绿假单胞菌疫苗被研发出来，并在小鼠保护研究中进行了评估。该疫苗主要由脂多糖和外膜蛋白组成，在被动和主动保护研究中均具有保护作用。一种针对该疫苗的兔抗血清在IgG组分中显示出高保护能力，并且在白细胞减少的小鼠模型中对6种攻击菌株中的3种具有保护作用。
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