Sourek J, Výmola F, Zelenková L
Zentralbl Bakteriol A. 1980 Mar;246(3):353-62.
The protective effect of the soluble immunogenic complex from Pseudomonas aeruginosa cell surface was studied on white mice. Vaccines were prepared from a single strain by phenol-water extraction or via preparing the Zn-complex. The immunogenic complex which contained the Pseudomonas "common protective antigen" as well as endotoxin and exotoxins in the form of toxoid, provided reliable protection if it was administered with aluminium hydroxide as adjuvant in three consecutive doses of 10, 100 and 500 microgram per 0.2 ml per mouse at 5-7 day intervals. Under these conditions, the monovaccine produced in mice a 90-100% protective effect against a lethal challenge dose (2 LD100) of toxic P. aeruginosa strains given a week after the last vaccine dose.
研究了铜绿假单胞菌细胞表面可溶性免疫原性复合物对小白鼠的保护作用。疫苗由单一菌株通过酚水提取法制备或通过制备锌复合物来制备。该免疫原性复合物含有铜绿假单胞菌“共同保护性抗原”以及类毒素形式的内毒素和外毒素，若以氢氧化铝作为佐剂，按每只小鼠0.2 ml连续三次给药，剂量分别为10、100和500微克，间隔5 - 7天，能提供可靠的保护。在这些条件下，在小鼠体内产生的单价疫苗对末次疫苗剂量一周后给予的致死性攻击剂量（2 LD100）的有毒铜绿假单胞菌菌株产生90 - 100%的保护作用。
