通过节段性非整倍体图谱检测影响黑腹果蝇RNA聚合酶活性的细胞遗传学区域。
Detection of cytogenetic regions influencing RNA polymerase activity in Drosophila melanogaster by segmental aneuploid mapping.
作者信息
Willms J, Phillips J
出版信息
Can J Genet Cytol. 1984 Dec;26(6):682-91. doi: 10.1139/g84-108.
In a search for loci with RNA polymerase related function, we have screened the Drosophila melanogaster genome for regions effective in eliciting a dosage response for total RNA polymerase activity using segmental aneuploids generated by the use of Y-autosome translocations. From this screen we have identified a total of six cytogenetically defined regions which elicit significant dosage response: a single X-chromosome region, 9C-11A, within which resides a known RNA polymerase locus and five noncontiguous regions on chromosome 3 with no previously identified RNA polymerase related function.
在寻找具有RNA聚合酶相关功能的基因座时，我们利用Y-常染色体易位产生的部分三体果蝇，对黑腹果蝇基因组进行了筛选，以寻找能有效引发总RNA聚合酶活性剂量反应的区域。通过该筛选，我们总共鉴定出六个细胞遗传学定义的区域，这些区域能引发显著的剂量反应：一个单一的X染色体区域，9C-11A，其中存在一个已知的RNA聚合酶基因座，以及位于3号染色体上的五个不连续区域，这些区域以前没有鉴定出与RNA聚合酶相关的功能。
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