飞蝗发育过程中其大脑中对章鱼胺和多巴胺敏感的腺苷酸环化酶
Octopamine- and dopamine-sensitive adenylate cyclase in the brain of Locusta migratoria during its development.
作者信息
Hiripi L, Rozsa K S
出版信息
Cell Mol Neurobiol. 1984 Sep;4(3):199-206. doi: 10.1007/BF00733585.
Octopamine- and dopamine-sensitive adenylate cyclases were studied in the brain of Locusta migratoria during its metamorphosis. In the adult brain the effects of octopamine and dopamine on adenylate cyclase were additive, suggesting the presence of separate populations of adenylate cyclase-linked receptors for octopamine and dopamine. There are no separate receptors for noradrenaline. Octopamine stimulates adenylate cyclase in both adult and larval brain; however, in adult brain octopamine is more potent than in larval brain. Dopamine stimulates adenylate cyclase activity only in adult brain. The sensitivity of adenylate cyclase to octopamine changes during the development of the animal. Phentolamine and cyproheptadine are potent antagonists of octopamine-stimulated adenylate cyclase, while propranolol has a weak effect. No cytosol factor which would modulate either basal or octopamine-stimulated adenylate cyclase was found. The effect of GTP and octopamine on adenylate cyclase was synergistic in adult brain but not in larval brain, while the effect of GppNHp and octopamine was synergistic in both adult and larval brains.
在飞蝗变态过程中，对其大脑中的章鱼胺和多巴胺敏感的腺苷酸环化酶进行了研究。在成体大脑中，章鱼胺和多巴胺对腺苷酸环化酶的作用是相加的，这表明存在与腺苷酸环化酶相连的、分别针对章鱼胺和多巴胺的不同受体群体。不存在去甲肾上腺素的单独受体。章鱼胺在成体和幼虫大脑中均能刺激腺苷酸环化酶；然而，在成体大脑中章鱼胺比在幼虫大脑中更有效。多巴胺仅在成体大脑中刺激腺苷酸环化酶活性。腺苷酸环化酶对章鱼胺的敏感性在动物发育过程中会发生变化。酚妥拉明和赛庚啶是章鱼胺刺激的腺苷酸环化酶的有效拮抗剂，而普萘洛尔的作用较弱。未发现可调节基础或章鱼胺刺激的腺苷酸环化酶的胞质溶胶因子。在成体大脑中，GTP和章鱼胺对腺苷酸环化酶的作用是协同的，但在幼虫大脑中不是，而GppNHp和章鱼胺的作用在成体和幼虫大脑中均是协同的。
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