成年致倦库蚊大脑中对多巴胺和章鱼胺敏感的腺苷酸环化酶
Dopamine- and octopamine-sensitive adenylate cyclase in the brain of adult Culex pipiens mosquitoes.
作者信息
Pratt S, Pryor S C
出版信息
Cell Mol Neurobiol. 1986 Sep;6(3):325-9. doi: 10.1007/BF00711117.
Abstract
The effects of dopamine and octopamine on adenylate cyclase activity were studied on the head homogenate of adult Culex pipiens mosquitoes in vitro. Both dopamine and octopamine were shown to increase the cyclic AMP content in the homogenate. The antagonist haloperidol blocked the production of cyclic AMP induced from dopamine but had no effect on the production of cyclic AMP induced by octopamine at the concentrations tested. The opiate agonist etorphine was ineffective at reducing cyclic AMP levels induced by either dopamine or octopamine at the concentrations tested.
摘要
在体外对成年致倦库蚊头部匀浆研究了多巴胺和章鱼胺对腺苷酸环化酶活性的影响。结果表明，多巴胺和章鱼胺均可增加匀浆中的环磷酸腺苷含量。拮抗剂氟哌啶醇可阻断多巴胺诱导的环磷酸腺苷生成，但在所测浓度下对章鱼胺诱导的环磷酸腺苷生成无影响。阿片类激动剂埃托啡在所测浓度下对降低多巴胺或章鱼胺诱导的环磷酸腺苷水平无效。
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