Bán A
Z Gesamte Inn Med. 1984 Dec 15;39(24):617-20.
It is reported on the occurrence of haemorrhagic complications at old age in patients treated with coumarin. Altogether 352 patients were examined, 96 of them were older than 70 years. A small part of the patients, above all men with obliterating vascular occlusions of the lower extremity were additionally given also thrombocyte aggregation inhibitors. The effective prothrombin level was nearly the same in the two, groups, i.e. in the patients younger and older than 70 years. There was no difference in frequency and severity of the haemorrhages with the exception of macrohaematuria which, however, appeared above all in the younger age group and in women older than 70 years. Under observation of the indications and with a regular control a long-term treatment with coumarin preparations can performed without any particular risk also at old age.
据报道，使用香豆素治疗的老年患者出现了出血并发症。总共检查了352名患者，其中96名年龄超过70岁。一小部分患者，尤其是患有下肢闭塞性血管阻塞的男性，还额外服用了血小板聚集抑制剂。两组患者（即70岁以下和70岁以上的患者）的有效凝血酶原水平几乎相同。除肉眼血尿外，出血的频率和严重程度没有差异，然而，肉眼血尿主要出现在较年轻的年龄组和70岁以上的女性中。在严格遵循适应证并定期监测的情况下，香豆素制剂的长期治疗在老年患者中也可进行，且无任何特殊风险。
