Ichihashi H, Mabuchi H, Suenaga M, Kondo T
Jpn J Surg. 1984 Nov;14(6):510-4. doi: 10.1007/BF02469795.
Tumor growth of Yoshida sarcoma implanted in the remnant liver was studied in rats subjected to a hepatectomy. After 70 percent hepatectomy, the liver progressively regenerated and the total liver weight was reverted to by 10 days after the operation. Concomitantly with liver regeneration, tumor growth in the remnant liver was stimulated significantly, compared with that in the sham-operated liver. Incorporation of tritiated thymidine into tumor cells in the remnant liver was strikingly high and progressive, while that in the sham-operated liver was low and retained. Mitomycin C given to the hepatectomized rats was more effective against the tumor in the remnant liver than in the sham-operated liver. We conclude from this study that cancer cell proliferation in the remnant liver can be accelerated by the process of liver regeneration.
在接受肝切除的大鼠中研究了移植于残余肝脏的吉田肉瘤的肿瘤生长情况。肝切除70%后，肝脏逐渐再生，术后10天时肝脏总重量恢复至术前水平。与假手术组肝脏相比，随着肝脏再生，残余肝脏中的肿瘤生长受到显著刺激。残余肝脏中肿瘤细胞的氚标记胸腺嘧啶核苷掺入量显著升高且持续增加，而假手术组肝脏中的掺入量较低且保持稳定。给予肝切除大鼠丝裂霉素C对残余肝脏肿瘤的疗效比对假手术组肝脏肿瘤的疗效更好。我们从这项研究得出结论，肝脏再生过程可加速残余肝脏中癌细胞的增殖。
