Tang G W, Chan S Y
Aust N Z J Obstet Gynaecol. 1984 Nov;24(4):280-2. doi: 10.1111/j.1479-828x.1984.tb01511.x.
Total 24-hour urinary oestrogen has been used extensively and proven to be reliable in monitoring gonadotrophin therapy for induction of ovulation. However, the method is time consuming for the patient and incomplete collection, as expected, is not uncommon, hence interfering with the treatment result. Oestrone-3-glucuronide in first morning urine samples has been shown to correlate well with plasma oestradiol-17 beta levels during normal menstrual cycles. A comparative study was made to examine the correlation between the levels of 24-hour urinary oestrogen and first morning urinary oestrogen in patients on gonadotrophin therapy. Creatinine levels were also determined to exclude the factor of variable excretion of oestrogen. The correlation thus found is highly significant (p less than 0.001). Hence first morning urinary oestrogen to creatinine ratios may be used to replace 24-hour urinary oestrogen in biochemical monitoring of gonadotrophin therapy.
24小时尿雌激素总量已被广泛应用，并被证明在监测促性腺激素诱导排卵治疗中是可靠的。然而，该方法对患者来说耗时较长，而且正如预期的那样，收集不完全的情况并不少见，从而干扰治疗结果。在正常月经周期中，晨尿样本中的雌酮-3-葡萄糖醛酸苷已被证明与血浆雌二醇-17β水平具有良好的相关性。进行了一项比较研究，以检查接受促性腺激素治疗的患者24小时尿雌激素水平与晨尿雌激素水平之间的相关性。还测定了肌酐水平，以排除雌激素排泄变化的因素。由此发现的相关性非常显著（p<0.001）。因此，晨尿雌激素与肌酐比值可用于替代24小时尿雌激素，对促性腺激素治疗进行生化监测。
