Frenkel Y, Eshkol A, Tikotzky D, Mashiach S, Lunenfeld B
Eur J Obstet Gynecol Reprod Biol. 1985 Jul;20(1):27-33. doi: 10.1016/0028-2243(85)90080-2.
HMG treatment is usually monitored by the evaluation of the cervical mucus, the determination of plasma 17 beta-estradiol, total urinary estrogens, ultrasonographic evaluation or a combination of these. We evaluated the daily validity of estrone-3-glucuronide excretion in urine as an indicator of follicular growth and maturation in 28 infertile women who were treated with HMG (Pergonal 500). Total urinary estrogens and estrone-3-glucuronide were measured in 24 h urine collections, and 11 of the women collected the early-morning urine separately. This allowed comparison of the concentrations and excretion of total estrogens and estrone-3-glucuronide of the 24 h urine with that found in the urine collected overnight. This comparison was made on 83 urine samples. The correlation between either the total excretion per 24 h or the concentration per liter in the 24 h urine collection of the two systems of determination was good in all determinations. Also in the urine collected on the day prior to HCG administration, total estrogens measurement was in good correlation with the estrone-3-glucuronide. However, there was statistically a significant difference in the concentrations of total estrogens and estrone-3-glucuronide between the women who ovulated and those who did not. Estrone-3-glucuronide, when calculated as a percentage of the total estrogens, was 60.86% in the women who ovulated and 33.15% in those who did not. These results demonstrate that although estrone-3-glucuronide reflects ovarian function in women treated with HMG, it may serve as a better predictor to ovulation.
人绝经期促性腺激素（HMG）治疗通常通过评估宫颈黏液、测定血浆17β - 雌二醇、总尿雌激素、超声检查或这些方法的联合应用来监测。我们评估了28例接受HMG（普果那500）治疗的不育女性尿中雌酮 - 3 - 葡萄糖醛酸苷排泄量作为卵泡生长和成熟指标的每日有效性。在24小时尿液收集样本中测量总尿雌激素和雌酮 - 3 - 葡萄糖醛酸苷，其中11名女性单独收集晨尿。这使得能够比较24小时尿液中总雌激素和雌酮 - 3 - 葡萄糖醛酸苷的浓度及排泄量与过夜收集尿液中的相应指标。对83份尿液样本进行了此项比较。在所有测定中，两种测定系统的24小时总排泄量或每升浓度之间的相关性均良好。同样在注射人绒毛膜促性腺激素（HCG）前一天收集的尿液中，总雌激素测量值与雌酮 - 3 - 葡萄糖醛酸苷也具有良好的相关性。然而，排卵女性和未排卵女性的总雌激素和雌酮 - 3 - 葡萄糖醛酸苷浓度在统计学上存在显著差异。以总雌激素的百分比计算时，排卵女性的雌酮 - 3 - 葡萄糖醛酸苷为60.86%，未排卵女性为33.15%。这些结果表明，虽然雌酮 - 3 - 葡萄糖醛酸苷反映了接受HMG治疗女性的卵巢功能，但它可能是排卵的更好预测指标。
