de Belleroche J, Recordati A, Rose F C
Neurochem Pathol. 1984 Spring;2(1):1-6. doi: 10.1007/BF02834167.
Amino acid levels in the cerebrospinal fluid of patients with motor neuron disease were compared with an age-matched control group receiving diagnostic myelography. Five amino acids were significantly elevated in the cerebrospinal fluid of the motor neuron disease patients compared to the controls. These were isoleucine, glycine, alanine, phenylalanine, and threonine, which were increased by 60, 58, 38, 26, and 25% respectively. A significant increase was also obtained when the amino acids with nonpolar R groups were grouped together (34%). The significance of these findings is discussed in terms of amino acid changes that occur in both normal aging and other neurological conditions.
将运动神经元病患者脑脊液中的氨基酸水平与接受诊断性脊髓造影的年龄匹配对照组进行了比较。与对照组相比，运动神经元病患者脑脊液中有五种氨基酸显著升高。这些氨基酸分别是异亮氨酸、甘氨酸、丙氨酸、苯丙氨酸和苏氨酸，其含量分别增加了60%、58%、38%、26%和25%。当将具有非极性R基团的氨基酸归为一组时，也获得了显著增加（34%）。根据正常衰老和其他神经疾病中发生的氨基酸变化对这些发现的意义进行了讨论。
