Clark H B
Department of Pathology (Division of Neuropathology), Washington University School of Medicine, St. Louis, MO 63110.
Semin Diagn Pathol. 1984 Nov;1(4):309-16.
Immunohistochemical localization of nervous system antigens is becoming an increasingly useful tool in the diagnosis of neuropathologic lesions. Use of antigen markers specific for certain cell types, when properly employed, can confirm suspected diagnoses or solve difficult differential diagnoses. Presently the most useful markers are the glial antigens, glial fibrillary acid protein and S-100 protein, but a number of other markers, such as neurofilament proteins and neuron-specific enolase, have shown some diagnostic utility.
神经系统抗原的免疫组织化学定位正日益成为神经病理学病变诊断中一种有用的工具。当正确使用时，针对某些特定细胞类型的抗原标志物能够证实可疑诊断或解决困难的鉴别诊断问题。目前，最有用的标志物是神经胶质抗原、胶质纤维酸性蛋白和S - 100蛋白，但其他一些标志物，如神经丝蛋白和神经元特异性烯醇化酶，也已显示出一定的诊断效用。
