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神经纤维肉瘤及其他软组织梭形细胞肉瘤中Leu-7的免疫反应性。

Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue.

作者信息

Swanson P E, Manivel J C, Wick M R

出版信息

Am J Pathol. 1987 Mar;126(3):546-60.

PMID:3103455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1899642/
Abstract

Monoclonal antibodies to Leu-7 have been reported to recognize a constituent of myelin-associated glycoprotein. Because of this, the authors studied 20 cases of neurofibrosarcoma (NFS), 7 of leiomyosarcoma (LMS), 3 of fibrosarcoma (FS), 8 of malignant fibrous histiocytoma (MFH), 5 of monophasic spindle cell synovial sarcoma (MSS), 5 of neurilemmoma, and 5 of neurofibroma for Leu-7 reactivity, to determine its utility in differential diagnosis. Selected examples of each tumor type were also studied ultrastructurally. Leu-7 was compared with the expression of S-100 protein, myelin basic protein, desmin, cytokeratin, and epithelial membrane antigen in the 43 neoplasms. Fifteen examples of NFS, 2 of LMS, and 2 of MSS were Leu-7+; 2 neurofibromas and 4 neurilemmomas also demonstrated reactivity with this antibody. In contrast, all cases of FS and MFH were Leu-7-. Synovial sarcomas could be effectively separated from NFS by reactivities for cytokeratin and epithelial membrane antigen in the former, but not the latter, lesions. However, LMSs and NFSs demonstrated significant immunocytochemical overlap, including shared positivity for S-100, desmin, and myelin basic protein in several cases. These results suggest that Leu-7 has restricted utility in immunohistochemical diagnosis, and must be utilized only in concert with other antigens. Moreover, it would appear that in selected instances, smooth-muscle and neurogenic sarcomas must be separated on the basis of clinical, histopathologic, and ultrastructural features alone.

摘要

据报道，针对Leu-7的单克隆抗体可识别髓鞘相关糖蛋白的一种成分。因此，作者研究了20例神经纤维肉瘤（NFS）、7例平滑肌肉瘤（LMS）、3例纤维肉瘤（FS）、8例恶性纤维组织细胞瘤（MFH）、5例单相梭形细胞滑膜肉瘤（MSS）、5例神经鞘瘤和5例神经纤维瘤的Leu-7反应性，以确定其在鉴别诊断中的效用。还对每种肿瘤类型的选定病例进行了超微结构研究。在43种肿瘤中，将Leu-7与S-100蛋白、髓鞘碱性蛋白、结蛋白、细胞角蛋白和上皮膜抗原的表达进行了比较。15例NFS、2例LMS和2例MSS为Leu-7阳性；2例神经纤维瘤和4例神经鞘瘤也显示出与该抗体的反应性。相比之下，所有FS和MFH病例均为Leu-7阴性。滑膜肉瘤可通过前者（而非后者）病变中细胞角蛋白和上皮膜抗原的反应性与NFS有效区分。然而，LMS和NFS表现出明显的免疫细胞化学重叠，包括几例病例中S-100、结蛋白和髓鞘碱性蛋白的共同阳性。这些结果表明，Leu-7在免疫组织化学诊断中的效用有限，必须仅与其他抗原联合使用。此外，在某些特定情况下，似乎必须仅根据临床、组织病理学和超微结构特征来区分平滑肌肉瘤和神经源性肉瘤。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e13/1899642/35a03b0449e6/amjpathol00150-0168-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e13/1899642/e93f9c1d8d1a/amjpathol00150-0160-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e13/1899642/d87aa76a7506/amjpathol00150-0164-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e13/1899642/56518c6bfe1a/amjpathol00150-0164-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e13/1899642/a47914dd6260/amjpathol00150-0161-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e13/1899642/0d4a3d0d701b/amjpathol00150-0163-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e13/1899642/c34a7a30d948/amjpathol00150-0163-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e13/1899642/a82d535d59db/amjpathol00150-0166-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e13/1899642/f00847dc36b3/amjpathol00150-0167-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e13/1899642/378e17d64ea3/amjpathol00150-0167-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e13/1899642/f1af04b543bb/amjpathol00150-0159-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e13/1899642/94ad40759bb0/amjpathol00150-0165-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e13/1899642/35a03b0449e6/amjpathol00150-0168-a.jpg

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