Nowell P C, Emanuel B S, Finan J B, Erikson J, Croce C M
Department of Pathology, School of Medicine, University of Pennsylvania, Philadelphia 19104.
Microbiol Sci. 1984 Dec;1(9):223-8.
Chromosomal studies have earlier provided evidence for the clonal nature of most neoplasms, and for the role of sequential genetic change in tumour progression. Now, in combination with molecular techniques, they are indicating how the function of specific genes (oncogenes) can be significantly altered by chromosomal translocations or by gene amplification, contributing to carcinogenesis.
染色体研究早期已为大多数肿瘤的克隆性质以及肿瘤进展过程中连续基因变化的作用提供了证据。现在，结合分子技术，这些研究正揭示特定基因（癌基因）的功能如何因染色体易位或基因扩增而发生显著改变，进而导致癌症发生。
