Lathrop J C, Frates R E
Cancer. 1980 Feb;45(3):432-8. doi: 10.1002/1097-0142(19800201)45:3<432::aid-cncr2820450305>3.0.co;2-c.
Sixty-two patients with intractable pelvic pain secondary to malignancy arising in the pelvis received a total of 72 percutaneous retrograde arterial infusions with nitrogen mustard. Fifty-three (74%) injections resulted in marked relief of pain for an average period of six to eight weeks. Five (7%) produced no pain relief. Toxicity was mild. There were two severe complications and no deaths related to the procedure or the drug in this study. Percutaneous retrograde arterial infusion with nitrogen mustard is suggested as the preferred procedure in the attempt to control pelvic pain caused by malignancy, before resorting to spinal cordotomy or intrathecal alcohol injection.
62例因盆腔恶性肿瘤导致顽固性盆腔疼痛的患者共接受了72次经皮逆行动脉注射氮芥治疗。53次（74%）注射使疼痛得到显著缓解，平均缓解期为6至8周。5次（7%）注射未缓解疼痛。毒性较轻。本研究中有2例严重并发症，且无与该操作或药物相关的死亡病例。在采取脊髓切断术或鞘内注射酒精之前，建议将经皮逆行动脉注射氮芥作为控制恶性肿瘤引起的盆腔疼痛的首选方法。
