Patt Y Z, Peters R E, Chuang V P, Wallace S, Claghorn L, Mavligit G
Cancer. 1985 Nov 1;56(9):2175-80. doi: 10.1002/1097-0142(19851101)56:9<2175::aid-cncr2820560906>3.0.co;2-3.
Twenty-one patients with inoperable colon cancer in the pelvis were treated with intra-arterial 5-fluorouracil (5-FU) and mitomycin C, given bilaterally into the internal iliac arteries. Seventeen of the 21 patients had failed previous radiation therapy and 15 had also failed systemic intravenous chemotherapy. Eighteen of the 21 patients received intra-arterial treatments because of pelvic pain. Effect of this treatment on the pain could be evaluated in 16 patients. A measurable decrease in pain medication occurred in 8 of 16, whereas a subjective feeling of pain relief was observed in 12 of 16 patients for a mean period of 3.5 months. However, objective tumor response was considered definite only if associated with a greater than 50% decline of an elevated plasma carcinoembryonic antigen level; this was observed in 5 of 11 patients (45%). Reduction in tumor mass as measured by imaging techniques was observed in two of ten patients in whom it was evaluable. Improvement in hydronephrosis was observed in five of seven evaluable patients. Hematuria was present in 12 patients and improved in 10 of those patients. The most significant side effect of chemotherapy was perineal and gluteal skin erythema, which was observed in 36% of the patients after the first course and in 24% during the second course. This frequently escalated to cutaneous vesiculation and desquamation. This side effect was prevented by concurrent administration of steroids. Pelvic arterial infusion of 5-FU and mitomycin C can offer temporary pain relief to patients who have failed other means of therapy. Objective antitumor effects may have also resulted but were much harder to assess in this group of patients.
21例盆腔内无法手术切除的结肠癌患者接受了双侧髂内动脉注射5-氟尿嘧啶（5-FU）和丝裂霉素C的治疗。21例患者中有17例既往放疗失败，15例既往全身静脉化疗也失败。21例患者中有18例因盆腔疼痛接受了动脉内治疗。可对16例患者评估该治疗对疼痛的效果。16例中有8例疼痛药物用量有可测量的减少，而16例中有12例患者主观感觉疼痛缓解，平均持续3.5个月。然而，只有当血浆癌胚抗原水平升高下降超过50%时，才认为有明确的客观肿瘤反应；11例患者中有5例（45%）出现这种情况。在10例可评估的患者中，通过成像技术测量发现有2例肿瘤体积缩小。7例可评估的患者中有5例肾积水得到改善。12例患者有血尿，其中10例有所改善。化疗最显著的副作用是会阴和臀部皮肤红斑，在第一个疗程后36%的患者中出现，第二个疗程期间24%的患者出现。这常常发展为皮肤水疱和脱皮。通过同时给予类固醇可预防这种副作用。盆腔动脉灌注5-FU和丝裂霉素C可为其他治疗方法失败的患者提供暂时的疼痛缓解。可能也产生了客观的抗肿瘤效果，但在这组患者中更难评估。
