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内毒素诱导的家兔血液图像变化。

Endotoxin-induced changes in the rabbit's blood picture.

作者信息

Konicková Z, Líkovský Z, Pávková L

出版信息

Physiol Bohemoslov. 1980;29(1):81-7.

PMID:6444742
Abstract

The authors studied changes in the rabbit's blood picture in the first 24 hours after the administration of three different doses of endotoxin. The most pronounced changes were observed in the white blood component, particularly the granulocytes, which almost vanished from the blood stream immediately after the endotoxin was injected. In 24 hours granulocytopenia was succeeded by marked granulocytosis. Changes in the lymphocytes were smaller; the lymphocyte count fell slightly about 3 hours after the injection of endotoxin, but by 24 hours it was almost normal again. The platelet count also fell after the administration of endotoxin, but the red blood picture remained virtually the same.

摘要

作者研究了给兔子注射三种不同剂量内毒素后最初24小时内其血液图像的变化。最明显的变化出现在白细胞成分中,尤其是粒细胞,在内毒素注射后粒细胞几乎立即从血流中消失。24小时内,粒细胞减少症之后是明显的粒细胞增多症。淋巴细胞的变化较小;注射内毒素约3小时后淋巴细胞计数略有下降,但到24小时时几乎又恢复正常。内毒素注射后血小板计数也下降,但红细胞图像基本保持不变。

相似文献

1
Endotoxin-induced changes in the rabbit's blood picture.内毒素诱导的家兔血液图像变化。
Physiol Bohemoslov. 1980;29(1):81-7.
2
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Changes in leukocyte count, blood glucose and coagulation system in calves injected with Escherichia coli endotoxin.注射大肠杆菌内毒素的犊牛白细胞计数、血糖及凝血系统的变化
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Influence of endotoxin on the level of tumor necrosis factor alfa and blood morphology in rats.内毒素对大鼠肿瘤坏死因子α水平及血液形态的影响。
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引用本文的文献

1
Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid.甲基泼尼松龙、F(ab')2 片段和迷迭香酸对兔内毒素诱导的血流动力学和血液学变化的影响
Br J Pharmacol. 1985 Feb;84(2):317-27. doi: 10.1111/j.1476-5381.1985.tb12916.x.