Abdou N I, Amare M, Sagawa A, Abdou N L
Transplantation. 1980 Apr;29(4):324-8. doi: 10.1097/00007890-198004000-00013.
To understand the mechanism by which deaggregated horse anti-human thymocyte globulin (dATG) fails to induce untoward immunological reactions in man, three patients who received ATG and two patients who received dATG were studied for evidence of sensitization or tolerance to the foreign globulin. The ATG but not the dATG recipients developed allergic or serum sickness reactions; antihorse serum antibody could be detected in their serum and their blood cells proliferated in vitro in the presence of horse serum and secreted antihorse serum antibodies (P less than 0.001). Tolerance of the dATG recipients was shown to be mediated by specific T suppressor cells that carry receptors for horse serum and could be detected in the blood of one patient, whom we have studied serially, 13 weeks after therapy. Deaggregated ATG does not induce allergic or serum sickness reactions. It induces tolerance to the foreign protein via the generation of specific short-lived suppressor cells.
为了解去聚合马抗人胸腺细胞球蛋白（dATG）在人体中未能引发不良免疫反应的机制，对3例接受ATG治疗的患者和2例接受dATG治疗的患者进行了研究，以寻找对这种异体球蛋白致敏或耐受的证据。接受ATG治疗的患者出现了过敏或血清病反应，而接受dATG治疗的患者未出现；在他们的血清中可检测到抗马血清抗体，并且他们的血细胞在马血清存在的情况下于体外增殖并分泌抗马血清抗体（P<0.001）。dATG接受者的耐受性被证明是由携带马血清受体的特异性T抑制细胞介导的，在治疗13周后，在一名接受了系列研究的患者血液中可检测到这些细胞。去聚合的ATG不会引发过敏或血清病反应。它通过产生特异性的短期抑制细胞诱导对异体蛋白的耐受性。
