Robin M M, Palfreyman M G, Zraika M M, Schechter P J
Eur J Pharmacol. 1980 Apr 4;62(4):319-27. doi: 10.1016/0014-2999(80)90099-0.
Unilateral intrastriatal injection of various substances induces a characteristic dyskinetic syndrome in rats. These substances include picrotoxin as well as a series of irreversible GABA-transaminase inhibitors. Using the degree of enzyme inhibition in various brain areas as a measure of drug distribution following intrastriatal administration of gamma-acetylenic GABA and gamma-vinyl GABA, there was found considerable retrodiffusion via the needle tract to the overlying cortex. Topical application of gamma-acetylenic GABA and gamma-vinyl GABA to the cortical surface overlying the striatum produced a high incidence of identical dyskinesias without any evidence of diffusion of drugs to the striatum. The cortically induced movements could be duplicated by picrotoxin application to a defined cortical area. These findings suggest that interference with gabaergic function in the striatum is not necessary for the production of the dyskinetic syndrome and that this syndrome may be a cortically induced phenomenon.
向大鼠单侧纹状体内注射各种物质会诱发一种特征性的运动障碍综合征。这些物质包括印防己毒素以及一系列不可逆的γ-氨基丁酸转氨酶抑制剂。在向纹状体内注射γ-乙炔基氨基丁酸和γ-乙烯基氨基丁酸后，以不同脑区的酶抑制程度作为药物分布的指标，发现药物通过针道大量逆向扩散至上方的皮质。将γ-乙炔基氨基丁酸和γ-乙烯基氨基丁酸局部应用于纹状体上方的皮质表面，会产生高发生率的相同运动障碍，且没有任何药物扩散至纹状体的证据。通过将印防己毒素应用于特定皮质区域，可以复制皮质诱导的运动。这些发现表明，纹状体内γ-氨基丁酸能功能的干扰对于运动障碍综合征的产生并非必要，且该综合征可能是一种皮质诱导现象。
