Myslobodsky M S, Ackermann R F, Golovchinsky V, Engel J
Pharmacol Biochem Behav. 1979 Nov;11(5):483-6. doi: 10.1016/0091-3057(79)90029-7.
Ketamine in a dose of 100 mg/kg (IP) produced stereotypic behavior and vigorous rotation in adult male Sprague-Dawley rats. The first rotation phase, accompanied by head swinging, was short and terminated by the anesthetic phase which lasted 20-30 min. The second rotation phase began 1-3 min after the end of the anesthetic phase. A single dose of GABA-T inhibitors, gamma-vinyl GABA (1200 mg/kg, IP) or gamma-acetylenic GABA (100 mg/kg, IP) administered 4 hours prior to ketamine, shortened the first rotation phase, increased the anesthetic phase, changed the pattern of postanesthetic rotation and reduced total and net rotation scores. Picrotoxin (3 mg/kg) given 10 min prior to ketamine tended to act in the opposite direction although none of its effects reached statistical significance.
以100毫克/千克的剂量腹腔注射氯胺酮，可使成年雄性斯普拉格-道利大鼠产生刻板行为和剧烈旋转。第一个旋转阶段伴有头部摆动，持续时间较短，并在持续20 - 30分钟的麻醉阶段结束。第二个旋转阶段在麻醉阶段结束后1 - 3分钟开始。在氯胺酮给药前4小时，单次腹腔注射γ-乙烯基γ-氨基丁酸（1200毫克/千克）或γ-乙炔基γ-氨基丁酸（100毫克/千克）这两种γ-氨基丁酸转氨酶抑制剂，可缩短第一个旋转阶段，延长麻醉阶段，改变麻醉后旋转模式，并降低总旋转得分和净旋转得分。在氯胺酮给药前10分钟注射印防己毒素（3毫克/千克），其作用倾向于相反方向，尽管其所有效应均未达到统计学显著性。
