痘苗病毒DNA中的反向末端重复序列编码早期mRNA。
Inverted terminal repetition in vaccinia virus DNA encodes early mRNAs.
作者信息
Wittek R, Barbosa E, Cooper J A, Garon C F, Chan H, Moss B
出版信息
Nature. 1980 May 1;285(5759):21-5. doi: 10.1038/285021a0.
DOI:10.1038/285021a0
PMID:6445508
Abstract
Vaccinia virus DNA contains a long inverted terminal repetition of MW approximately 6.8 x 10(6). A fragment of MW 6.3 X 10(6) from this repetition has been cloned in coliphage lambda and used to isolate RNA from virus-infected cells. Electron microscopy indicates that early RNAs are transcribed from the repeated sequence and cell-free translation shows that the RNAs code for polypeptides.
摘要
痘苗病毒DNA含有一个分子量约为6.8×10⁶的长反向末端重复序列。从该重复序列中分离出一个分子量为6.3×10⁶的片段，克隆到大肠杆菌噬菌体λ中，并用于从病毒感染细胞中分离RNA。电子显微镜检查表明，早期RNA是从重复序列转录而来的，无细胞翻译表明这些RNA编码多肽。
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