Borel Y, Young M C
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1593-6. doi: 10.1073/pnas.77.3.1593.
The concept of using cell-bound antigens as tolerogen was applied to nucleic acid. Nucleoside was linked directly to spleen cell suspensions. Intravenous administration of nucleoside coupled to isogeneic spleen cells into mice generated suppressor cells that diminished the formation of antibody-forming cells either to a T-dependent antigen in vivo or to a T-independent antigen in vitro. Suppressor cells were nucleoside specific, but the specificity of immune suppression seems to be somewhat broader than that of tolerance to a single nucleoside. The ability to raise nucleic acid-specific suppressor T cells may have implications for both the pathogenesis and treatment of systemic lupus erythematosus.
将细胞结合抗原作为耐受原的概念应用于核酸。核苷直接与脾细胞悬液相连。将与同基因脾细胞偶联的核苷静脉注射到小鼠体内，可产生抑制细胞，这些抑制细胞可减少体内针对T细胞依赖性抗原或体外针对T细胞非依赖性抗原的抗体形成细胞的形成。抑制细胞具有核苷特异性，但免疫抑制的特异性似乎比单一核苷耐受性的特异性更广。培养核酸特异性抑制性T细胞的能力可能对系统性红斑狼疮的发病机制和治疗都有影响。
