2-烟酰胺基乙基硝酸酯（SG-75）对犬离体心房变时性和变力性的差异作用

Differential chronotropic and inotropic effects of 2-nicotinamidoethyl nitrate (SG-75) in the dog isolated atrium.

Chiba S, Furukawa Y, Kobayashi M

Clin Exp Pharmacol Physiol. 1980 Mar-Apr;7(2):205-8. doi: 10.1111/j.1440-1681.1980.tb00062.x.

Abstract

The chronotropic and inotropic effects of the anti-anginal agent SG-75 (2-nicotinamidoethyl nitrate) and 1-verapamil were investigated in isolated blood-perfused canine atrial preparations. The compounds were administered via the cannulated sinus node artery. 2. SG-75 induced a selective negative inotropic as opposed to a chronotropic effect. Verapamil showed no selective negative chronotropic or inotropic activity. 3. Effects of SG-75 and 1-verapamil on the frequency-force relationship were studied. SG-75 produced a uniform depression of the developed tension at all frequencies tested which the depression with 1-verapamil was greater at higher than at lower frequencies.

摘要

在离体血液灌注的犬心房制备物中研究了抗心绞痛药物SG - 75（2 - 烟酰胺基乙基硝酸盐）和维拉帕米的变时性和变力性作用。这些化合物通过插管的窦房结动脉给药。2. SG - 75产生选择性负性变力作用，而非变时性作用。维拉帕米未表现出选择性负性变时性或变力性活性。3. 研究了SG - 75和维拉帕米对频率 - 力关系的影响。SG - 75在所有测试频率下均使所产生的张力均匀降低，而维拉帕米在较高频率时的降低幅度大于较低频率时。